Research Fellow, Drug Metabolism and Pharmacokinetics (DMPK) | BioNJ Talent Services

Research Fellow, Drug Metabolism and Pharmacokinetics (DMPK)

Contact Information
Contact Name: 
PTC Therapeutics
Organization Name: 
PTC Therapeutics
Position Location: 
South Plainfield
Company Profile: 

Translating Science. Transforming Lives.

Our mission at PTC Therapeutics has always been to build an integrated biopharmaceutical company based on our expertise in RNA biology. We have focused on discovering and developing novel oral treatments for patients with serious and life-limiting disorders. By targeting the processes that modulate RNA biology and affect protein production, we bring an innovative approach to drug discovery. We are focused particularly on the development and commercialization of treatments for rare and neglected disorders.

Commitment to Patients.

We are committed to finding treatment options for patients living with life-threatening diseases. Our lead product candidate is ataluren for the treatment of patients with genetic disorders due to a nonsense mutation. Ataluren is in clinical development for the treatment of nonsense mutation Duchenne muscular dystrophy (nmDMD). Ataluren has been approved under the trade name Translarna™ in the European Union for ambulatory patients with nmDMD who are 5 years and older.

Job Description:

The Research Fellow, DMPK is responsible for the leading and providing DMPK research and project management support for small molecule drug discovery programs.
The incumbent works cross-functionally with internal departments and external resources as part of PTC’s discovery science project teams. He/She is specifically responsible for performing DMPK research, interpreting data and providing timely DMPK-related support to the broader research team(s). This includes, but may not be limited to, discovery chemistry, biology and preclinical pharmacology as well as external Contract Research Organizations (CROs).
The Research Fellow, DMPK ensures adherence to relevant regulatory requirements and company Standard Operating Procedures (SOPs) as appropriate.

Primary duties/responsibilities:
• Performs hands-on drug metabolism and pharmacokinetic (DMPK) research and bioanalytical testing in support of drug discovery programs using Liquid Chromatography – Mass Spectrometry (LC-MS/MS).
• Collaborates closely with discovery chemistry, biology and preclinical pharmacology teams to manage project timelines.
• Ensures the scientific quality of the DMPK data in support of drug discovery.
• Liaises with, supports and strengthens PTC’s relationships with external CROs.
• Develops and writes protocols, study reports and IND documents as appropriate.
• Represents the DMPK department at the discovery team project meetings. Interprets and presents DMPK scientific data/results.
• Performs other tasks and assignments as needed and specified by management.

Qualifications: 

Minimum level of education and years of relevant work experience.

• PhD in Chemistry or other related scientific discipline and a minimum of 7 years of relevant and progressively responsible experience in drug metabolism and PK in a pharmaceutical, biotechnology or related environment OR equivalent experience and/or education.

* Special knowledge or skills required.

• Demonstrated proficiency and hands-on experience in DMPK research and LC-MS/MS bioanalysis.
• Experience in managing projects.
• Demonstrated experience writing study reports and regulatory documents.
• Demonstrated leadership ability.
• Ability to influence without direct authority.
• Proficiency with Microsoft Office.
• Excellent verbal and written communication and skills.
• Ability to work independently and collaboratively, as required, in a fast-paced, matrixed, team environment consisting of internal and external team members.
• Analytical thinker with excellent problem solving skills and the ability to adapt to changing priorities and deadlines.
• Excellent planning, organization and time management skills including the ability to support and prioritize multiple projects.

*Special knowledge or skills preferred.

• Experience managing, coaching and mentoring direct reports.

Additional Job or Internship Information
Position Type: 
Full time job
Function: 
Research and Development